• The effect of blood pressure on cognitive performance. An 8-year follow-up of the Tromsø Study, comprising people aged 45–74 Years 

      Hestad, Knut; Engedal, Knut; Schirmer, Henrik; Strand, Bjørn Heine (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-21)
      <i>Background</i>: The relationship between blood pressure (BP) and cognition is complex were age appears to be an intervening variable. High and low BP have been associated with cognitive deficits as part of the aging process, but more studies are needed, especially in more recent birth cohorts.<p><p> <i>Methods</i>: The study sample comprised 4,465 participants, with BP measured at baseline in ...
    • High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders 

      Neupane, Sudan Prasad; Lien, Lars; Martinez, Priscilla; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Hestad, Knut; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-03)
      <p><i>Aims - </i>As major depression (MD) is often comorbid with alcohol‐use disorders (AUD) and alcohol itself modulates the immune system, we examined serum levels of interleukin (IL)‐6, IL‐10, tumor necrosis factor (TNF), and interferon (IFN)‐γ in AUD patients with and without MD. Putative interactions between alcohol variables and MD on cytokine levels were also assessed. <p><i>Methods - </i>A ...
    • PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress 

      Toft, Helge Prytz; Bramness, Jørgen Gustav; Lien, Lars; Abebe, Dawit Shawel; Wampold, Bruce E.; Tilden, Terje; Hestad, Knut; Neupane, Sudan Prasad (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-17)
      <p><i>Background</i>: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric treatment. We aimed to explore circulating cytokines and assess psychiatric symptom severity scores during 12 weeks of inpatient psychiatric treatment.</p> <p><i>Methods</i>: ...